Autoresponder php/MySQL

We would need an autoresponder for our website. Data base is MySQL, script is php. Clients would have to confirm in the first mailing that they really have subscribed. Then, they would need to have the option to unsubscribe in every mail by clicking on the bottom line text link. They would have to get emailed material in regular times, that we can upload easily and in advance. It would be helpful if clients could get personalized letters (calling them by their name). It would also be good if we can upload elsewhere purchased opt in email lists.